SARMS: Ostarine MK 2866
What is Ostarine?
Ostarine is an anabolic compound that also goes by the names Enbosarm and MK-2866. It is classified as a SARM or Selective Androgen Receptor Modulator. It was invented by James T. Dalton and other researchers at the University of Tennessee, Ohio State, and GTx Incorporated. SARMs are substances that modulate the androgen receptors which are the targets of testosterone and other steroids, producing effects which may be similar to those of anabolic steroids. SARMs do not have the structure of typical steroids. SARMS are banned for use by athletes by the World Anti-Doping Agency.
Figure 1. Many companies make and sell ostarine, this is typically what it looks like. A user might use about half a dropper which may be about 25 mg.
Ostarine bodybuilding history
By 1997, non-steroidal androgen agonists had been developed and patents were applied for them by groups researching at the University of Tennessee.
By 2008, SARMS were being researched in the treatment of muscle wasting. Research into Ostarine has been lead by GTx. Phase II clinical trials have been confirmed but the status of the compound is no longer known. Phase III trials to treat muscle wasting in severely ill persons failed to reach primary endpoints.
Many companies have begun selling ostarine and similar substances as research chemicals, as it is not an approved drug regulated by the US FDA.
Athletes have begun using ostarine and other SARMS to improve muscle mass and recovery.
How Does Ostarine Work?
Ostarine is a selective androgen receptor modulator. This means that it agonizes or modulates the androgen receptor, the target of hormones like testosterone. It is selective for skeletal muscle in an attempt to produce fewer side effects than anabolic steroids. Agonist effects at androgen receptors may increase protein synthesis, increase muscle mass, improve recovery, and increase wound healing. It may have fewer masculinizing effects at hair follicles, the voice box, produce less acne than anabolic steroids, and have fewer effects at downregulating androgen receptors in the testes.
What is ostarine used for?
Ostarine is used mainly by athletes and biohackers for the same purposes anabolic steroids are used. It is used mainly to improve recovery ability from intense workouts. In this context, it may improve muscle mass and recovery.
How Can Ostarine be taken?
For males, for muscle wasting and medical use, it is taken at 3 mg per day.
For males for bodybuilding and athletics, male users take as much as 25 mg per day.
Females take as much as 10 mg per day for bodybuilding and athletic gains.
Ostarine cycle length
This is taken in a cycle lasting from one to 3 months, after which you need to take some time off to allow the body to readjust.
Ostarine MK-2866 buy
Ostarine appears to be becoming less available as it is in a regulatory grey area at the moment but still can be bought pretty easily from various companies selling research chemicals, often not for human use.
One such company is ELV Biosciences. They sell ostarine as MK-2866
Is Ostarine Legal?
Ostarine appears to be legal to buy and sell in the United States but check your local laws. It has already been banned by the World Anti-Doping Agency because it provides an anabolic effect that can give an unfair advantage in athletic competition and because safety is not guaranteed. It is sold most often as a research chemical, often not labeled for human consumption.
The drug has made it to at least Phase IIa trials for conditions like muscle wasting, but the dosages used are generally low and the effects and side effects are kept to a minimum so it’s not clear if the drug will provide the medical effects wanted with an acceptable side effect profile. Therefore, we do not yet know what the final outcome will be for this substance. It could become a prescription drug, or it could fail trials and become another discarded anabolic substance, sometimes used by bodybuilders.
What are the benefits of ostarine?
Possible Side Effects
Personal Experience: Ostarine for Fibromyalgia
I bought Ostarine from ELV Biosciences. It is labeled MK-2866 and has 50 mg per mL. I decided to take 25 mg per day from doing research on the internet. This is the dose used by people who use it for bodybuilding purposes. I decided to use this dose to test the effects. Note that 1mg to 3 mg per day is typically used in studies for issues like muscle wasting. Their goal is simply to stop muscle loss in people who do not work out. The lower dose is expected to have fewer side effects. Side effects of ostarine at a higher dose can include testosterone suppression and raised liver enzymes which could indicate liver damage. These are known effects of oral anabolic steroids, so they are somewhat expected. However, SARMS have a different structure, so the side effects may be different or fewer. It is not yet known what the long-term side effects might be; therefore anyone using it in any way other than as a research chemical would have to do so at their own risk.
I have fibromyalgia. It is a condition that features widespread muscle pain and weakness, extreme fatigue, exercise intolerance, and poor exercise recovery ability. I considered many anabolics to help with recovery during what is called fibromyalgia crashes. I tried ostarine in the past for this, and found it will get you out of bed during a crash but only at the higher dose, 25 mg. I used it only during crashes at the time. This time, I decided to use it daily to see if it might also prevent crashes.
I used 25 mg, which is half a dropper. I started exercising a bit more when able to, doing treadmill exercise, push-ups, dips, and pull-ups. I do only one set because in the past, recovery was difficult and exercise could cause a crash.
Overall, I noticed that ostarine will definitely get you out of bed after a crash. It seems to work minutes after dosing and if you feel tired it will give you a slight sense that you are less heavy, but it doesn’t give you mental energy like a stimulant. Somehow though, you do feel a bit brighter simply due to not feeling so heavy. I’m 160 lbs., 6 ft tall male by the way. I’m actually surprisingly muscular for my inability to do much exercise. My guess is that the muscles break down more easily and there is more inflammation due to fibromyalgia and Ehlers-Danlos syndrome. Therefore muscle tissue breaks down easier and inflames, which looks muscular but it’s not efficient.
There is no noticeable increase or decrease in libido. There is no jaundice which indicates liver damage, though that doesn’t mean there is no damage. There is a dramatic increase in strength and reduction of fatigue. However, most of these effects are not felt unless you workout beyond your usual ability. It restores muscle pump, strength, and ability.
For fibromyalgia-related stressors, I would give this substance an A. However, side effects are unknown. After one month, I plan to reduce or stop the dose. I have tried skipping a day and there is no noticeable fatigue, therefore, quitting should be easy unless you have a crash during the days that you’ve quit. In which case, you can take another dose if you have to work, or just wait it out.
The main risk which we are aware of is that this substance could temporarily or permanently decrease the sensitivity of anabolic receptors, in which case you could become feminized or swell up fat like a balloon unless you use an anabolic. It may also suppress testosterone production which could lead to shrinking testicles. Lastly, reckless use could damage the liver. I have not seen any of these side effects at the dosage I’ve taken over the course of one month, so hopefully, we got through the cycle with few side effects.
Ostarine suppresses testosterone less than typical anabolic steroids and is selective for muscle tissue so it is expected to have fewer side effects than exogenous testosterone but this is merely speculation from low doses used in studies.
Q & A
Q: Would I continue using ostarine?
A: The overall answer is no. I might use it sporadically to recover from crashes. The reason I would not want to continue to use it is that long-term side effects are unknown and I already use too many supplements and medications for which I have to watch out for side effects. This is a high-risk substance until more is known about it.
I’ve been using dextromethorphan, an ingredient in Robitussin gels, and well as gabapentin and these have greater effects on symptoms of fibromyalgia than ostarine. This suggests to me that fibromyalgia in my case is caused mostly by a derangement in blood availability caused by overactive vagus response due to the structural, nervous system, and autoimmune anomalies, not caused by actual insufficient muscle viability. The muscles themselves are probably not very much damaged, it’s the nervous system and immune system. You, therefore, get marginal effects from anabolics.
Q: Would I recommend ostarine to others?
A: I can’t make any recommendations, I’m not a doctor. I can only say that it helped me with recovery. If I were to continue using it, I would only use it to recover from crashes, therefore I would have to worry much less about side effects or testosterone suppression.
Q: Would you try other SARMS like trestolone rad 140?
A: I would not. The benefits for fibromyalgia seem marginal. However, I would keep a SARM for use in emergencies and I would probably choose ostarine because it has more human studies done.
Q: How long do sarms stay in your system?
A: We’ve found information for a different SARM called ligandrol. The half-life is 24 hours. After two days, 25% will still be in your system. After 4 days it should be undetectable. We can possibly extrapolate this same schedule to ostarine.
Q: What are the best sarms for women?
A: If a woman had a medical condition and SARMS had been medicalized and prescribed by a doctor, I imagine they could prescribe 1 to 3 mg of ostarine for a woman with muscle wasting. If a bodybuilder was using it, a woman might use 10 mg per day of ostarine.
The Wisdom of Social media. What are people saying about ostarine?
“drop in T is negligible…”
This ostarine user on Reddit gives a fair assessment. He finds the SARM to be more anabolic than training without it, but not as anabolic as typical anabolic steroids. He finds there to be negligible but tangible testosterone suppression.
“…preserves ALL your gains…”
This user echoes many of the experiences we’ve seen about ostarine. He did not notice much testosterone suppression and effects on libido were minimal. He feels the substance is mildly anabolic and good for maintaining muscle mass during ‘cutting’, or fat loss.
“…I was making newb-like strength gains…”
This Reddit weightlifter claims to have gotten immediate and lasting gains in strength and recovery ability. He also added an inch to his biceps which is very impressive to people who actually measure their biceps.
Ostarine is a promising substance. It absolutely has anabolic effects, greater than say creatine, but less than traditional anabolic steroids.
However, this substance is a high risk, for the high-risk biohacker. Although side effects appear to be mild, long-term side effects and side effects in offspring are unknown.
From personal experience: This substance is effective and there are no noticeable short-term side effects after a 1-month cycle.
For biohackers, the following risk assessment is critical. You don’t want to end up using a long list of substances with unknown long-term risks as that practically guarantees you will run into a problem and not know which substance is causing it. Always do this risk assessment and more before you use any substance.
Overall Risk: High
|This is suitable for the high risk, chance-taking biohacker.|
|How long have humans used this substance?||It appears to be totally new, but the structure has not been publicly revealed.|
|Did animals Co-evolve with the substance?||No.|
|Did humans co-evolve with the substance?||NO.|
|How synthetic is it? How much has it been altered from a natural substance?||Highly synthetic, not similar to testosterone.|
|How long as it been on the market?||Has not made it through trials yet, sold as a research chemical.|
|What do post-clinical reports say?||No such reports.|
|Is it used medically?||Yes, in clinical research.|
|Are side effects severe?||They do not appear to be; however, long-term side effects are not known.|
|Is it easy to overdose?||It does not appear to be easy to overdose through the exact LD50 is unknown.|
This image from social media is claimed to be after six weeks of using ostarine. You be the judge.
General Medical Disclaimer
NCSM is not dispensing medical advice.
Ostarine is not regulated as a drug by the United States of America FDA. In the USA, ostarine as of June 2019 is not a prescription drug meant to treat, diagnose, or prevent disease.
- 1 SARMS: Ostarine MK 2866
- 2 Ostarine bodybuilding history
- 3 How Does Ostarine Work?
- 4 What is ostarine used for?
- 5 How Can Ostarine be taken?
- 6 Is Ostarine Legal?
- 7 Personal Experience: Ostarine for Fibromyalgia
- 8 Q & A
- 9 The Wisdom of Social media. What are people saying about ostarine?
- 10 Conclusion
- 11 Overall Risk: High
- 12 General Medical Disclaimer